Invention Grant
- Patent Title: Pyridazino-pyridinone compounds and methods of use
- Patent Title (中): 哒嗪 - 吡啶酮化合物及其使用方法
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Application No.: US13060663Application Date: 2009-08-26
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Publication No.: US08455495B2Publication Date: 2013-06-04
- Inventor: Liping H. Pettus , Andrew Tasker , Hui-Ling Wang , Bin Wu , Ryan Wurz
- Applicant: Liping H. Pettus , Andrew Tasker , Hui-Ling Wang , Bin Wu , Ryan Wurz
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent G. Prabhakar Reddy
- International Application: PCT/US2009/055093 WO 20090826
- International Announcement: WO2010/025201 WO 20100304
- Main IPC: A01N43/58
- IPC: A01N43/58 ; A61K31/50 ; C07D237/26

Abstract:
The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A, R1, R2, R3, R4, R5, R6, X and n are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of p38 map kinase mediated diseases including rheumatoid arthritis, psoriasis, chronic obstructive pulmonary disease, pain and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
Public/Granted literature
- US20110275629A1 Pyridazino-pyridinone Compounds and Methods of Use Public/Granted day:2011-11-10
Information query
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