Invention Grant
- Patent Title: 3-hydroxy-5-arylisoxazole derivative
- Patent Title (中): 3-羟基-5-芳基异恶唑衍生物
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Application No.: US13504749Application Date: 2010-10-29
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Publication No.: US08455500B2Publication Date: 2013-06-04
- Inventor: Akihiro Okano , Munetaka Ohkouchi
- Applicant: Akihiro Okano , Munetaka Ohkouchi
- Applicant Address: JP Tokyo
- Assignee: Mochida Pharmaceutical Co., Ltd.
- Current Assignee: Mochida Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Birch, Stewart, Kolasch and Birch, LLP
- Priority: JP2009-251493 20091030; JP2009-281014 20091210
- International Application: PCT/JP2010/069380 WO 20101029
- International Announcement: WO2011/052756 WO 20110505
- Main IPC: A61K31/505
- IPC: A61K31/505 ; A61K31/4427 ; A61K31/42 ; C07D413/02 ; C07D413/00 ; C07D261/06 ; C07D239/24

Abstract:
[Problem]To provide a GPR40 activating agent having, as an active ingredient, a novel compound having a GPR40 agonist action, a salt of the compound, a solvate of the salt or the compound, or the like, particularly, an insulin secretagogue and a prophylactic and/or therapeutic agent against diabetes, obesity, or other diseases.[Means of Solving the Problem]A compound of Formula (I): (where p is 0 to 4; j is 0 to 3; k is 0 to 2; a ring A is a specific cyclic group; a ring B is a benzene ring, a pyridine ring, or a pyrimidine ring; X is —CH2—, O, —S(O)i— (i is 0 to 2), or —NR7—; R1 to R6 are specific groups), a salt of the compound, or a solvate of the salt or the compound.
Public/Granted literature
- US20120220772A1 NOVEL 3-HYDROXY-5-ARYLISOXAZOLE DERIVATIVE Public/Granted day:2012-08-30
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