Invention Grant
- Patent Title: Diaminoalkane aspartic protease inhibitors
- Patent Title (中): 二氨基烷烃天冬氨酸蛋白酶抑制剂
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Application No.: US12802142Application Date: 2010-05-28
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Publication No.: US08455521B2Publication Date: 2013-06-04
- Inventor: John J. Baldwin , David A. Claremon , Colin M. Tice , Salvacion Cacatian , Lawrence W. Dillard , Alexey V. Ishchenko , Jing Yuan , Zhenrong Xu , Gerard McGeehan , Wei Zhao , Robert D. Simpson , Suresh B. Singh , Patrick T. Flaherty , Jean-Pierre Wery
- Applicant: John J. Baldwin , David A. Claremon , Colin M. Tice , Salvacion Cacatian , Lawrence W. Dillard , Alexey V. Ishchenko , Jing Yuan , Zhenrong Xu , Gerard McGeehan , Wei Zhao , Robert D. Simpson , Suresh B. Singh , Patrick T. Flaherty , Jean-Pierre Wery
- Applicant Address: US PA Fort Washington
- Assignee: Vitae Pharmaceuticals, Inc.
- Current Assignee: Vitae Pharmaceuticals, Inc.
- Current Assignee Address: US PA Fort Washington
- Agency: Hamilton, Brook, Smith & Reynolds, P.C.
- Main IPC: C07D417/04
- IPC: C07D417/04 ; C07D409/06 ; C07D405/06 ; C07D401/06 ; C07D417/06 ; C07D265/30 ; C07D211/22 ; C07D211/26 ; A61K31/5377 ; A61K31/5375 ; A61K31/445 ; A61K31/4525 ; A61K31/453 ; A61K31/4535 ; A61K31/454 ; A61K31/4545

Abstract:
Diaminoalkanes of below Formula I have now been found which are orally active and bind to aspartic proteases to inhibit their activity: They are useful in the treatment or amelioration of diseases associated with elevated levels of aspartic protease activity. The invention also relates to a method for the use of the compounds of Formula I in ameliorating or treating aspartic protease related disorders in a subject in need thereof comprising administering to said subject an effective amount of a compound of Formula I.
Public/Granted literature
- US20110105506A1 Diaminoalkane aspartic protease inhibitors Public/Granted day:2011-05-05
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