Invention Grant
US08455530B2 Crystalline form of an alkoxyimidazol-1-ylmethyl biphenyl carboxylic acid
有权
烷氧基咪唑-1-基甲基联苯羧酸的结晶形式
- Patent Title: Crystalline form of an alkoxyimidazol-1-ylmethyl biphenyl carboxylic acid
- Patent Title (中): 烷氧基咪唑-1-基甲基联苯羧酸的结晶形式
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Application No.: US13411319Application Date: 2012-03-02
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Publication No.: US08455530B2Publication Date: 2013-06-04
- Inventor: Robert S. Chao , Weijiang Zhang
- Applicant: Robert S. Chao , Weijiang Zhang
- Applicant Address: US CA South San Francisco
- Assignee: Theravance, Inc.
- Current Assignee: Theravance, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Shelley Eberle
- Main IPC: A61K31/415
- IPC: A61K31/415 ; C07D233/54
Abstract:
The invention provides a crystalline freebase form of 4′-{2-ethoxy-4-ethyl-5-[((S)-2-mercapto-4-methylpentanoylamino)methyl]imidazol-1-ylmethyl}-3′-fluorobiphenyl-2-carboxylic acid. This invention also provides pharmaceutical compositions comprising the crystalline compound, processes and intermediates for preparing the crystalline compound, and methods of using the crystalline compound to treat diseases such as hypertension.
Public/Granted literature
- US20120309805A1 CRYSTALLINE FORM OF AN ALKOXYIMIDAZOL-1-YLMETHYL BIPHENYL CARBOXYLIC ACID Public/Granted day:2012-12-06
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