Invention Grant
US08455552B2 Composition comprising S-allylmercapto-N-acetylcysteine (ASSNAC) for up-regulation of cellular glutathione level
有权
包含用于上调细胞谷胱甘肽水平的S-烯丙基巯基-N-乙酰半胱氨酸（ASSNAC）的组合物
- Patent Title: Composition comprising S-allylmercapto-N-acetylcysteine (ASSNAC) for up-regulation of cellular glutathione level
- Patent Title (中): 包含用于上调细胞谷胱甘肽水平的S-烯丙基巯基-N-乙酰半胱氨酸（ASSNAC）的组合物
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Application No.: US12597956Application Date: 2008-05-01
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Publication No.: US08455552B2Publication Date: 2013-06-04
- Inventor: Naphtali Savion , David Mirelman , Aharon Rabinkov , Alex Khenkin
- Applicant: Naphtali Savion , David Mirelman , Aharon Rabinkov , Alex Khenkin
- Applicant Address: IL Tel Aviv IL Rehovot
- Assignee: RAMOT et Tel Aviv University Ltd.,Yeda Research and Development Co. Ltd.
- Current Assignee: RAMOT et Tel Aviv University Ltd.,Yeda Research and Development Co. Ltd.
- Current Assignee Address: IL Tel Aviv IL Rehovot
- Agency: Booth Udall Fuller, PLC
- Agent Rodney J. Fuller
- International Application: PCT/IL2008/000600 WO 20080501
- International Announcement: WO2008/135984 WO 20081113
- Main IPC: A01N41/12
- IPC: A01N41/12 ; A61K31/105 ; C07C321/00 ; C07C323/00 ; C07C381/00
Abstract:
The present invention relates to S-allylmercapto-N-acetylcysteine (ASSNAC) and its pharmaceutically acceptable salts and solvates, which are useful for up-regulation of cellular glutathione levels and expression of phase II detoxifying enzymes. The invention further provides methods of use thereof in the prevention, alleviation or treatment of oxidative stress induced by reactive oxygen species (ROS).
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