Invention Grant
- Patent Title: Influenza A virus vaccines and inhibitors
-
Application No.: US12706804Application Date: 2010-02-17
-
Publication No.: US08455621B2Publication Date: 2013-06-04
- Inventor: Robert M. Krug , Karen Y. Twu , Rei-Lin Kuo , Gaetano Montelione , Edward Arnold , Kalyan Das , LiChung Ma , Rong Xiao
- Applicant: Robert M. Krug , Karen Y. Twu , Rei-Lin Kuo , Gaetano Montelione , Edward Arnold , Kalyan Das , LiChung Ma , Rong Xiao
- Applicant Address: US NJ New Brunswick US TX Austin
- Assignee: Rutgers, The State University of New Jersery,Board of Regents, The University of Texas System
- Current Assignee: Rutgers, The State University of New Jersery,Board of Regents, The University of Texas System
- Current Assignee Address: US NJ New Brunswick US TX Austin
- Agency: Chalker Flores, LLP
- Agent Chainey P. Singleton; Edwin S. Flores
- Main IPC: C07K1/00
- IPC: C07K1/00
Abstract:
The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
Public/Granted literature
- US20100247569A1 Influenza A Virus Vaccines and Inhibitors Public/Granted day:2010-09-30
Information query
