Invention Grant
- Patent Title: HDAC inhibitors
- Patent Title (中): HDAC抑制剂
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Application No.: US13426417Application Date: 2012-03-21
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Publication No.: US08455688B2Publication Date: 2013-06-04
- Inventor: John S. Kovach , Francis Johnson
- Applicant: John S. Kovach , Francis Johnson
- Applicant Address: US NY East Setauket
- Assignee: Lixte Biotechnology, Inc.
- Current Assignee: Lixte Biotechnology, Inc.
- Current Assignee Address: US NY East Setauket
- Agency: Cooper & Dunham LLP
- Agent John P. White; Gary J. Gershik
- Main IPC: C07C233/65
- IPC: C07C233/65 ; A61K31/16

Abstract:
This invention provides the compound having the structure wherein n is 1-10; X is C—R11 or N, wherein R11 is H, OH, SH, F, Cl, SO2R7, NO2, trifluoromethyl, methoxy, or CO—R7, wherein R7 is alkyl, alkenyl, alkynyl, C3-C8 cycloalkyl, or aryl; Z is R2 is H or NR3R4, wherein R3 and R4 are each independently H, C1-C6 alkyl, or C3-C8 cycloalkyl; R5 is OH or SH; and R6, R12, R13, and R14 are each independently H, OH, SH, F, Cl, SO2R15, NO2, trifluoromethyl, methoxy, or CO—R15, wherein R15 is alkyl, alkenyl, alkynyl, C3-C8 cycloalkyl, or aryl, or a salt of the compound, which is useful in the treatment of tumors.
Public/Granted literature
- US20120178783A1 HDAC INHIBITORS Public/Granted day:2012-07-12
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