An interface circuit for controlling a cross-domain signal link between a first circuit domain and a second circuit domain in a circuit may include first and second controllers, each of the first and second controllers including a first input coupled to a first voltage source of the first circuit domain and a second input coupled to a second voltage source of the second circuit domain. The interface circuit may further include a first switch controlled by an output of the first controller, the first switch including a first end coupled to the cross-domain signal link and a second end coupled to a first defined voltage state, and a second switch controlled by an output of the second controller, the second switch including a first end coupled to the cross-domain signal link and a second end coupled to a second defined voltage state, in which during a power-up of the circuit, if one of the first and second voltage sources is unavailable, at least one of the first and second controllers generates a control signal to engage at least one of the first and second switches and pull the cross-domain signal link to one of the first and second defined voltage states, while providing cross-domain protection against field-induced charge device model (FICDM) stress conditions at small drivers and receiver inputs connected to the signal interface link.