A voltage operation system includes: a power on reset circuit, a voltage detecting circuit, an operating signal generating circuit, and an electronic fuse circuit. The power on reset circuit is used for generating a power on reset signal. The voltage detecting circuit detects an operating voltage to output a voltage detecting signal. The operating signal generating circuit, coupled to the power on reset circuit and the voltage detecting circuit-outputs an operating signal. The electronic fuse circuit can be fused according to a lock signal, a fuse signal, and the operating signal.