Methods and apparatus to avoid mobile station transmission of duplicate event-based and polled acknowledgments are disclosed. An example method for a mobile station configured to send event-based acknowledgment information as disclosed herein comprises classifying a downlink data block as unreported, receiving a poll from a network requesting the mobile station to send polled acknowledgment information during a period, and refraining from sending during the period event-based acknowledgment information for the downlink data block classified as unreported.