A radiosurgery system is configured to deliver a therapeutic dose of radiation to a target structure in a patient. The target tissues are placed in a global coordinate system based on ocular imaging. The target tissues inside the global coordinate system lead to direction of an automated positioning system that is directed based on the target tissues within the coordinate system. A treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. A fiducial marker is used to identify the location of the target tissues. The device automatically turns off with excessive movement outside of alignment along an axis of the eye. Radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.