A safe in-ear earphone for radiation protection comprises earplug heads, sound cavities, acoustic wave transmission channels, a main body, a conductor and a plug. The channels are set between the sound cavities and loudspeakers. The acoustic wave concentrated orifices are between the loudspeakers and the acoustic wave transmission channels. The assembly of the loudspeakers, the acoustic wave concentrated orifices and the acoustic wave transmission channels are sealed to form a sealed small boxes in the main body. The shape of acoustic wave concentrated orifices is inverse loudhailer. The acoustic wave is transmitted to the two acoustic wave channels via the acoustic wave concentrated orifices and then is provided to the ears plugged by two earplugs to listen.