Wireless computer mouse operation may be provided by receiving a user detection signal from a sensor of the wireless computer mouse to determine the presence of a user. In one embodiment, an operation mode of the wireless computer mouse may be determined by a controller based, at least in part, on the user detection signal. Thereafter, the controller can enable at least one of a short range wireless communication module and a global positioning receiver of the wireless computer mouse based on the operation mode determined by the controller.