A method in a transmitter including a transmission chain and a Power Amplifier (PA), includes storing calibration data relating a plurality of specified output power levels of the transmitter to respective PA control voltages for application to the PA and respective gain levels for application to the transmission chain that cause the transmitter to output signals at the specified output power levels. A target output power level is specified, and an actual control voltage is applied to the PA. The actual control voltage is derived from a specified target control voltage depending on the target output power. A modified gain level which, when applied to the transmission chain while the PA is controlled with the actual control voltage, causes the transmitter to output the signals at the target output power level, is computed based on the calibration data. The modified gain level is applied to the transmission chain.