A method and system for predictively controlling environmental conditions of multiple occupancy zones in an occupancy space are provided. Occupancy and environmental conditions of each of the occupancy zones are detected and identified. The detected occupancy is stored in an occupancy database. Patterns of occupancy of each of the occupancy zones are determined using the occupancy database. Future occupancy of the occupancy zones is predicted based on the occupancy patterns of the occupancy zones. The environmental conditions of the occupancy zones are controlled based on the detected occupancy and/or the predicted future occupancy. The environmental conditions of the occupancy zones in the occupancy space are thereby predictively controlled by simultaneously incorporating an occupant's desired settings, existing and historical temperature data within the occupancy space, and weather data. The predicted occupancy can be combined with demand response signal and energy tier rates to make optimal conditioning decisions.