Invention Grant
US08457902B2 Method for selecting SIRNAs from a plurality of SIRNAs for gene silencing
有权
用于从多个SIRNA中选择用于基因沉默的SIRNA的方法
- Patent Title: Method for selecting SIRNAs from a plurality of SIRNAs for gene silencing
- Patent Title (中): 用于从多个SIRNA中选择用于基因沉默的SIRNA的方法
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Application No.: US13100836Application Date: 2011-05-04
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Publication No.: US08457902B2Publication Date: 2013-06-04
- Inventor: Aimee L. Jackson , Steven R. Bartz , Julja Burchard , Peter S. Linsley , Ge Wei , Guy L. Cavet
- Applicant: Aimee L. Jackson , Steven R. Bartz , Julja Burchard , Peter S. Linsley , Ge Wei , Guy L. Cavet
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agency: Christensen O'Connor Johnson Kindness PLLC
- Main IPC: G06F7/00
- IPC: G06F7/00
Abstract:
The present invention provides a method for identifying siRNA target motifs in a transcript using a position-specific score matrix approach. The invention also provides a method for identifying off-target genes of an siRNA using a position-specific score matrix approach. The invention further provides a method for designing siRNAs with higher silencing efficacy and specificity. The invention also provides a library of siRNAs comprising siRNAs with high silencing efficacy and specificity.
Public/Granted literature
- US20110250591A1 METHOD OF DESIGNING siRNAS FOR GENE SILENCING Public/Granted day:2011-10-13
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