Invention Grant
- Patent Title: Method for determining gene knockouts
- Patent Title (中): 确定基因敲除的方法
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Application No.: US13210484Application Date: 2011-08-16
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Publication No.: US08457941B2Publication Date: 2013-06-04
- Inventor: Costas D. Maranas , Anthony R. Burgard , Priti Pharkya
- Applicant: Costas D. Maranas , Anthony R. Burgard , Priti Pharkya
- Applicant Address: US PA University Park
- Assignee: The Penn State Research Foundation
- Current Assignee: The Penn State Research Foundation
- Current Assignee Address: US PA University Park
- Agency: McKee, Voorhees & Sease, P.L.C.
- Main IPC: G06G7/48
- IPC: G06G7/48
Abstract:
A method for determining candidates for gene deletions and additions using a model of a metabolic network associated with an organism, the model includes a plurality of metabolic reactions defining metabolite relationships, the method includes selecting a bioengineering objective for the organism, selecting at least one cellular objective, forming an optimization problem that couples the at least one cellular objective with the bioengineering objective, and solving the optimization problem to yield at least one candidate.
Public/Granted literature
- US20110301930A1 METHOD FOR DETERMINING GENE KNOCKOUTS Public/Granted day:2011-12-08
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