Systems and methods are provided for use in managing the regionalization of print media. In one system, a master data file having a plurality of different print features may be examined to identify at least one of the print features as a candidate print feature for possible modification in at least one region. For each candidate print feature, the system may receive user input to selectively establish a secondary data file for a print media campaign targeting at least the region in which the print candidate feature may be modified based, at least in part, on an existing regionalized print feature or on a requested regionalized print feature.