Methods and systems are provided for hardware-based pattern matching. In an embodiment, an intrusion-prevention system (IPS) identifies a full match between a subject data word comprising subject-data blocks and a signature data pattern comprising signature-data blocks. The IPS receives the subject data word via a network interface, and thereafter makes a partial-match determination that two or more but less than all of the subject-data blocks respectively match the same number of the signature-data blocks stored in partial-match hardware with respect to both value and position. Thereafter, the IPS makes a full-match determination that all of the subject-data blocks respectively match all of the signature-data blocks stored in the IPS's full-match hardware with respect to both value and position. The IPS then stores an indicator that the full-match determination has been made, and may carry out one or more additional intrusion-prevention responses as well.