Systems and methods are provided for prioritizing an order in which to process a plurality of sub-regions of an acquired image of an optical code. A method of processing an optical code in a data reader comprises the steps of receiving data corresponding to a plurality of sub-regions of an acquired image of an optical code, processing according to a processing order the plurality of sub-regions for decodable data corresponding to the optical code, determining based on the step of processing the plurality of sub-regions whether one or more of the plurality of sub-regions contains decodable data, and if it is determined that a sub-region contains decodable data, increasing the processing priority associated with said sub-region. If one or more of the sub-regions having the highest processing priority contains decodable data, the remaining sub-regions do not need to be processed, which may save processing resources and increase the read throughput.