Invention Grant
- Patent Title: Interferon alpha receptor I antibodies and their use
- Patent Title (中): 干扰素α受体I抗体及其用途
-
Application No.: US12704948Application Date: 2010-02-12
-
Publication No.: US08460668B2Publication Date: 2013-06-11
- Inventor: Josephine M. Cardarelli , Alison Witte , Mohan Srinivasan
- Applicant: Josephine M. Cardarelli , Alison Witte , Mohan Srinivasan
- Applicant Address: US NJ Princeton
- Assignee: Medarex, Inc.
- Current Assignee: Medarex, Inc.
- Current Assignee Address: US NJ Princeton
- Agency: Baker Botts L.L.P.
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C12P21/08
Abstract:
The present invention provides isolated human monoclonal antibodies that bind to IFNAR-1 and that are capable of inhibiting the biological activity of Type I interferons. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting Type I interferon-mediated disorders using the antibodies of the invention, including methods for treating autoimmune disorders, transplant rejection or Graft Versus Host Disease using the antibodies of the invention.
Public/Granted literature
- US20100143369A1 Interferon Alpha Receptor I Antibodies And Their Use Public/Granted day:2010-06-10
Information query
