Invention Grant
- Patent Title: Solvent/polymer solutions as suspension vehicles
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Application No.: US13647228Application Date: 2012-10-08
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Publication No.: US08460694B2Publication Date: 2013-06-11
- Inventor: Catherine M. Rohloff , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
- Applicant: Catherine M. Rohloff , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
- Applicant Address: US CA Hayward
- Assignee: Intarcia Therapeutics, Inc.
- Current Assignee: Intarcia Therapeutics, Inc.
- Current Assignee Address: US CA Hayward
- Agent Gary R. Fabian; Barbara G. McClung
- Main IPC: A61F2/00
- IPC: A61F2/00 ; A61K9/22 ; A61K9/14 ; A61K45/00 ; A61K38/00

Abstract:
A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.
Public/Granted literature
- US20130035670A1 SOLVENT/POLYMER SOLUTIONS AS SUSPENSION VEHICLES Public/Granted day:2013-02-07
Information query
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