Invention Grant
US08460864B2 Methods for identifying compounds that modulate untranslated region-dependent gene expression and methods of using same
有权
用于鉴定调节非翻译区域依赖性基因表达的化合物的方法及其使用方法
- Patent Title: Methods for identifying compounds that modulate untranslated region-dependent gene expression and methods of using same
- Patent Title (中): 用于鉴定调节非翻译区域依赖性基因表达的化合物的方法及其使用方法
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Application No.: US10543033Application Date: 2004-01-21
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Publication No.: US08460864B2Publication Date: 2013-06-11
- Inventor: Liangxian Cao , Panayiota Trifillis
- Applicant: Liangxian Cao , Panayiota Trifillis
- Applicant Address: US NJ South Plainfield
- Assignee: PTC Therapeutics, Inc.
- Current Assignee: PTC Therapeutics, Inc.
- Current Assignee Address: US NJ South Plainfield
- Agency: Jones Day
- International Application: PCT/US2004/001643 WO 20040121
- International Announcement: WO2004/065561 WO 20040805
- Main IPC: C40B40/04
- IPC: C40B40/04
Abstract:
The present invention relates to methods for identifying compounds that modulate untranslated region-dependent expression of a target gene. The invention particularly relates to using untranslated regions of a target gene or fragments thereof linked to a reporter gene to identify compounds that modulate untranslated region-dependent expression of a target gene. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads.
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