Invention Grant
- Patent Title: Variable domains of camelid heavy-chain antibodies directed against glial fibrillary acidic proteins
- Patent Title (中): 针对胶质纤维酸性蛋白的骆驼重链抗体的可变结构域
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Application No.: US13002910Application Date: 2009-07-07
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Publication No.: US08460888B2Publication Date: 2013-06-11
- Inventor: Pierre Lafaye , Jean-Pierre Bourgeois , Francois Rougeon
- Applicant: Pierre Lafaye , Jean-Pierre Bourgeois , Francois Rougeon
- Applicant Address: FR Paris
- Assignee: Institut Pasteur
- Current Assignee: Institut Pasteur
- Current Assignee Address: FR Paris
- Agency: Foley & Lardner LLP
- Priority: EP08290683 20080710
- International Application: PCT/IB2009/006596 WO 20090707
- International Announcement: WO2010/004432 WO 20100114
- Main IPC: G01N33/567
- IPC: G01N33/567 ; C07K16/18 ; C07K16/28 ; A61K39/395
Abstract:
The present invention relates to the use of variable domains of camelid heavy-chain antibodies (VHH domains) directed against an intracellular target and having an isoelectric point of at least 8.5, for targeting said intracellular target or for the preparation of a peptide vector. Particularly, it concerns VHH domains directed against a glial fibrillary acidic protein and uses thereof for preparing therapeutic or diagnostic agents.
Public/Granted literature
- US20110250211A1 VARIABLE DOMAINS OF CAMELID HEAVY-CHAIN ANTIBODIES DIRECTED AGAINST GLIAL FIBRILLARY ACIDIC PROTEINS Public/Granted day:2011-10-13
Information query
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