Invention Grant
- Patent Title: Dibenzoazepine and dibenzooxazepine TRPA1 agonists
- Patent Title (中): 二苯并氮杂和二苯并氧氮杂TRPA1激动剂
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Application No.: US12746092Application Date: 2008-12-04
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Publication No.: US08461145B2Publication Date: 2013-06-11
- Inventor: Henricus Jacobus Maria Gijsen , Marc Hubert Mercken
- Applicant: Henricus Jacobus Maria Gijsen , Marc Hubert Mercken
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE Beerse
- Agent Michael J. Atkins
- Priority: EP07122339 20071205; EP08157200 20080529
- International Application: PCT/EP2008/066813 WO 20081204
- International Announcement: WO2009/071631 WO 20090611
- Main IPC: A61K31/55
- IPC: A61K31/55 ; A61K31/553 ; C07D233/20 ; C07D267/20 ; A61P25/00
Abstract:
The present invention is related to novel tricyclic compounds of formula (I) having TRPA1 receptor agonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use as pharmacological tools, or as irritant incapacitants, or in the treatment of diseases linked to the modulation of the TRPA1 receptors in animals, in particular humans.
Public/Granted literature
- US20100273773A1 DIBENZOAZEPINE AND DIBENZOOXAZEPINE TRPA1 AGONISTS Public/Granted day:2010-10-28
Information query
