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Invention Grant
US08461150B2 Chalcone linked pyrrolo[2,1-c][1, 4]benzodiazepine hybrids as potential anticancer agents and process for the preparation thereof 有权
查耳酮连接的吡咯并[2,1-c] [1,4]苯并二氮杂杂环化合物作为潜在的抗癌剂及其制备方法

Chalcone linked pyrrolo[2,1-c][1, 4]benzodiazepine hybrids as potential anticancer agents and process for the preparation thereof
Abstract:
The present invention relates to chalcone linked pyrrolo[2,1-c][1,4]benzodiazepine hybrids and a process for the preparation there of. More particularly it relates to 7-Methoxy-8-{n[4-1-(2 or 4-substituted phenyl)-3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-one]alkyl}-oxy}-(11aS)-1,2,3,11a-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one and 7-Methoxy-8-{n-[-3-(4-hydroxy-3-methoxyphenyl)-1-(2,4-alkyl-3-quinolyl)-2-propen-1-one]alkyl}-oxy-(11aS)-1,2,3,11a-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one with aliphatic chain length variations useful as anticancer (antitumor) agent. The general structural formula of these chalcone linked pyrrolo[2,1-c][1,4]benzodiazepines hybrids is given below. wherein R1=OH, methyl, ethyl or phenyl; R2=H, OH or F; R=H or methyl; x=c or N; n=1-4.
Abstract(Chinese):

本发明涉及查耳酮连接的吡咯并[2,1-c] [1,4]苯并二氮杂杂环化合物及其制备方法。 更特别地，它涉及7-甲氧基-8- {n [4-1-（2或4-取代的苯基）-3-（4-羟基-3-甲氧基苯基）-2-丙烯-1-酮]烷基} 氧基} - （11aS）-1,2,3,11a-5H-吡咯并[2,1-c] [1,4]苯并二氮杂_-酮和7-甲氧基-8- {正 - 4-氨基-3-甲氧基苯基）-1-（2,4-烷基-3-喹啉基）-2-丙烯-1-酮]烷基} - 氧 - （11aS）-1,2,3,11a- 吡咯并[2,1-c] [1,4]苯并二氮杂-5-酮，其具有用作抗癌剂（抗肿瘤剂）的脂肪族链长度变化。 这些查耳酮连接的吡咯并[2,1-c] [1,4]苯并二氮杂杂环化合物的一般结构式如下。 其中R1 = OH，甲基，乙基或苯基; R2 = H，OH或F; R = H或甲基; x = c或N; n = 1-4。

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