Invention Grant
US08461163B2 Substituted N-(pyrazolo[1,5-a]pyrimidin-5-yl)amides as inhibitors of apoptosis signal-regulating kinase 1
有权
取代的N-（吡唑并[1,5-a]嘧啶-5-基）酰胺作为凋亡信号调节激酶1的抑制剂
![Substituted N-(pyrazolo[1,5-a]pyrimidin-5-yl)amides as inhibitors of apoptosis signal-regulating kinase 1](/docs/US/2013-06-11/US08461163B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted N-(pyrazolo[1,5-a]pyrimidin-5-yl)amides as inhibitors of apoptosis signal-regulating kinase 1
- Patent Title (中): 取代的N-（吡唑并[1,5-a]嘧啶-5-基）酰胺作为凋亡信号调节激酶1的抑制剂
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Application No.: US12935542Application Date: 2009-03-30
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Publication No.: US08461163B2Publication Date: 2013-06-11
- Inventor: Edcon Chang , Tracy Duong , Takehiro Hirano , Matthew H. McNiell , Yoshito Terao , Angie Vassar
- Applicant: Edcon Chang , Tracy Duong , Takehiro Hirano , Matthew H. McNiell , Yoshito Terao , Angie Vassar
- Applicant Address: JP Osaka
- Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee Address: JP Osaka
- Agent Matthew J. Russo; C. Amy Smith
- International Application: PCT/US2009/038840 WO 20090330
- International Announcement: WO2009/123986 WO 20091008
- Main IPC: A01N43/90
- IPC: A01N43/90 ; A61K31/519
![Substituted N-(pyrazolo[1,5-a]pyrimidin-5-yl)amides as inhibitors of apoptosis signal-regulating kinase 1](/abs-image/US/2013/06/11/US08461163B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to apoptosis signal-regulating kinase 1 (“ASK1”) . inhibiting compounds of the formula wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds, to methods and intermediates useful for making the compounds, and to methods of using the compounds.
Public/Granted literature
- US20110077235A1 APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS Public/Granted day:2011-03-31
Information query
IPC分类:
