Invention Grant
US08461308B2 Monoclonal antibodies against prostate specific membrane antigen (PSMA) lacking in fucosyl residues
有权
针对缺乏岩藻糖残基的前列腺特异性膜抗原（PSMA）的单克隆抗体
- Patent Title: Monoclonal antibodies against prostate specific membrane antigen (PSMA) lacking in fucosyl residues
- Patent Title (中): 针对缺乏岩藻糖残基的前列腺特异性膜抗原（PSMA）的单克隆抗体
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Application No.: US12903853Application Date: 2010-10-13
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Publication No.: US08461308B2Publication Date: 2013-06-11
- Inventor: Josephine M. Cardarelli , David B. Passmore , Jenny Albanese , Lei Zhu
- Applicant: Josephine M. Cardarelli , David B. Passmore , Jenny Albanese , Lei Zhu
- Applicant Address: US NJ Princeton
- Assignee: Medarex, Inc.
- Current Assignee: Medarex, Inc.
- Current Assignee Address: US NJ Princeton
- Agency: Nelson Mullins Riley & Scarborough LLP
- Agent Jane E. Remillard; Jill Gorny Sloper
- Main IPC: C07K16/30
- IPC: C07K16/30
Abstract:
The invention pertains to anti-PSMA antibodies that lack fucosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity as compared to the fucosylated form of the antibodies. The invention also provides host cells that express the anti-PSMA antibodies that lack fucosyl residues, wherein the host cells are deficient for a fucosyl transferase. Methods of using the antibodies to inhibit the growth of PSMA+ cells, such as tumor cells, are also provided.
Public/Granted literature
- US20110028696A1 MONOCLONAL ANTIBODIES AGAINST PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) LACKING IN FUCOSYL RESIDUES Public/Granted day:2011-02-03
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