Invention Grant
- Patent Title: (1R, 1′R)-atracurium salts separation process
- Patent Title (中): （1R，1'R） - 盐酸盐分离过程
-
Application No.: US12529269Application Date: 2008-03-05
-
Publication No.: US08461338B2Publication Date: 2013-06-11
- Inventor: Oded Arad , Elena Ostrovsky
- Applicant: Oded Arad , Elena Ostrovsky
- Applicant Address: IL Bnei Brak
- Assignee: Chemagis Ltd.
- Current Assignee: Chemagis Ltd.
- Current Assignee Address: IL Bnei Brak
- Agency: Leydig, Voit & Mayer, Ltd.
- International Application: PCT/IL2008/000289 WO 20080305
- International Announcement: WO2008/107887 WO 20080912
- Main IPC: C07D401/12
- IPC: C07D401/12
Abstract:
The present invention provides an improved method of chromatographically separating the isomers of (1R,rR)-atracurium salts by high-performance liquid chromatography (HPLC), in the absence of a strong acid. The separation is preferably performed on a silica gel HPLC column using an eluent containing an organic solvent, a polar aprotic co-solvent and a weak organic acid.
Public/Granted literature
- US20100099878A1 (1R, 1'R)-ATRACURIUM SALTS SEPARATION PROCESS Public/Granted day:2010-04-22
Information query
