Invention Grant
- Patent Title: Fluorescent probe for measuring protease
- Patent Title (中): 用于测量蛋白酶的荧光探针
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Application No.: US13201537Application Date: 2010-02-19
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Publication No.: US08461358B2Publication Date: 2013-06-11
- Inventor: Tetsuo Nagano , Yasuteru Urano , Masayo Sakabe
- Applicant: Tetsuo Nagano , Yasuteru Urano , Masayo Sakabe
- Applicant Address: JP Toyko
- Assignee: The University of Tokyo
- Current Assignee: The University of Tokyo
- Current Assignee Address: JP Toyko
- Agency: Greenblum & Bernstein, P.L.C.
- Priority: JP2009-037284 20090220
- International Application: PCT/JP2010/001077 WO 20100219
- International Announcement: WO2010/095450 WO 20100826
- Main IPC: C07D313/00
- IPC: C07D313/00 ; A61K39/00

Abstract:
A compound represented by the formula (I) or a salt thereof (R1 represents hydrogen atom, or a substituent; R2 to R7 represent hydrogen atom, hydroxyl group, an alkyl group, or a halogen atom; R8 and R9 represent hydrogen atom, or an alkyl group; X represents a C1-C3 alkylene group; and R10 represents an acyl group), which promptly causes a structural change from a non-fluorescent closed ring structure to a strongly fluorescent open ring structure by hydrolysis of an acyl group, and is useful as a fluorescent probe for measuring a protease showing superior suitability for quantification.
Public/Granted literature
- US20120052518A1 FLUORESCENT PROBE FOR MEASURING PROTEASE Public/Granted day:2012-03-01
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