Invention Grant
- Patent Title: Optically active cyclic alcohol compound
- Patent Title (中): 光学活性环状醇化合物
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Application No.: US13087588Application Date: 2011-04-15
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Publication No.: US08471028B2Publication Date: 2013-06-25
- Inventor: Masaki Okamoto , Akira Sakuragi , Yoshikazu Mori , Muneki Kishida , Takanori Higashijima
- Applicant: Masaki Okamoto , Akira Sakuragi , Yoshikazu Mori , Muneki Kishida , Takanori Higashijima
- Applicant Address: JP Osaka-Shi
- Assignee: Mitsubishi Tanabe Pharma Corporation
- Current Assignee: Mitsubishi Tanabe Pharma Corporation
- Current Assignee Address: JP Osaka-Shi
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- Priority: JP2005-290756 20051004
- Main IPC: C07D401/04
- IPC: C07D401/04

Abstract:
The present invention relates to a method for preparing an optically active cyclic alcohol compound represented by general formula [I]: [wherein R represents a hydrogen atom or a protecting group for amino group, and * represents an asymmetric carbon atom.] which comprises a step of subjecting a cyclic ketone compound represented by general formula [II]: [wherein R has the same meaning as defined above.] to asymmetric reduction (A) in the presence of an optically active oxazaborolidine compound and a boron hydride compound, or (B) in the presence of an asymmetric transition metal complex obtained from a transition metal compound and an asymmetric ligand and a hydrogen donor, and relates to said compound.
Public/Granted literature
- US20110196157A1 OPTICALLY ACTIVE CYCLIC ALCOHOL COMPOUND AND METHOD FOR PREPARING THE SAME Public/Granted day:2011-08-11
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