An overvoltage and overcurrent protection circuit includes a connection jack, an overvoltage protection switch connected to the connection jack, an overcurrent protection switch, a voltage reference module, an overvoltage and overcurrent detection module, a comparing module, and a current control module. The overcurrent protection switch is connected to the overvoltage protection switch in serials, and further connected to a load. The voltage reference module is to output a reference voltage. The overvoltage and overcurrent detection module is to detect the voltage of the load and the current of the path. The comparing module is to compare the voltage of the load with the reference voltage, when greater, turns off the overvoltage protection switch, when not greater, turns on the overvoltage protection switch. The current control module is to turn off the overcurrent protection switch if greater than the preset value, and turn on the overcurrent protection switch if not greater.