A clear, sealable isolation sleeve for use in a medical environment especially with hand-held electronic devices, for the purpose of reducing the spread of infectious diseases. The sleeve offers an isolated containment for such hand-held medical devices while in patient proximity. The sleeve features a perforated tear zone for easy removal and disposal. Embodiments of the present invention can be manufactured from a clear material that allows the hand-held device to read bar codes through it, while also allowing the clinician to read displayed data and manipulate keypads on the device all while contained within the sleeve.