A closed system for surgical limb prep has: a two-layered construction, including an inner layer and a top layer; or a three-layered construction, including an inner layer, an intermediate layer, and a top layer. The inner layer fits over and engages the limb of the patient, and the inner layer also serves as a storage medium for a topical antiseptic or other prep fluid. The intermediate layer, if present, is positioned over the inner layer and is preferably made of a substantially waterproof or fluid-resistant material. The top layer covers the other layer(s) and includes one or more strips of adhesive that can be used to secure the top layer to the limb of the patient, effectively sealing and closing the system about the limb of the patient.