A surgical clip applier includes a handle assembly, a first clip assembly, and a second clip assembly. The first clip assembly is adapted to receive only a single clip while the second clip assembly is adapted to receive multiple clips. The handle assembly is sized and configured to receive the first clip assembly or the second clip assembly. A jaw assembly includes a pair of jaws each with an elongate support arm, and a bridge holding the jaws in an aligned relationship. A housing has a fixed relationship with the bridge while permitting movement of the jaws between an open and a closed state. A coupling attaches the housing to the handle assembly. An associated method of operation includes the step of removing one of the single clip jaw assembly and the multiple clip-jaw assembly, disposing of the one jaw assembly while mounting the other jaw assembly on the handle.