The airflow regulation system is to be attached to a residual limb of an amputee. The device includes an airflow liner to define a regulated environment between the residual limb and the airflow liner. The liner has a plurality of airflow passageways defining inflow air channels and an outflow air channel in fluid communication with the defined regulated environment. An airflow control system is connected inline with the outflow and inflow air channels. The airflow control system includes an airflow regulation device, such as a vacuum pump, and an airflow initiating device, such as a solenoid.