Invention Grant
US08475798B2 Monoclonal antibodies recognizing a coagulase-negative staphylococcal protein
有权
识别凝固酶阴性葡萄球菌蛋白的单克隆抗体
- Patent Title: Monoclonal antibodies recognizing a coagulase-negative staphylococcal protein
- Patent Title (中): 识别凝固酶阴性葡萄球菌蛋白的单克隆抗体
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Application No.: US11917435Application Date: 2006-06-16
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Publication No.: US08475798B2Publication Date: 2013-07-02
- Inventor: Joseph M. Patti , Jeff T. Hutchins , Andrea Hall , Linda Santos , Maria Bowden , Magnus Hook
- Applicant: Joseph M. Patti , Jeff T. Hutchins , Andrea Hall , Linda Santos , Maria Bowden , Magnus Hook
- Applicant Address: US GA Alpharetta US TX College Station
- Assignee: Inhibitex, Inc.,The Texas A&M University System
- Current Assignee: Inhibitex, Inc.,The Texas A&M University System
- Current Assignee Address: US GA Alpharetta US TX College Station
- Agency: Stites & Harbison, PLLC
- Agent B. Aaron Schulman, Esq.
- International Application: PCT/US2006/023590 WO 20060616
- International Announcement: WO2006/138627 WO 20061228
- Main IPC: A61K39/40
- IPC: A61K39/40 ; A61K39/00 ; A61K39/395 ; G01N33/569
Abstract:
Monoclonal antibodies which can bind to the SdrF protein of Staphylococcus epidermidis are provided which can be useful in the treatment and protection against infection from staphylococcal bacteria such as Staphylococcus epidermidis. The monoclonal antibodies of the invention are advantageous in that they can also recognize binding domains and subdomains of the S. epidermidis SdrF protein in addition to the protein itself. Suitable compositions and passive vaccines based on the monoclonal antibodies of the invention, as well as methods for their use, are also provided.
Public/Granted literature
- US20100183623A1 MONOCLONAL ANTIBODIES RECOGNIZING A COAGULASE-NEGATIVE STAPHYLOCOCCAL PROTEIN Public/Granted day:2010-07-22
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