Invention Grant
- Patent Title: Probe and method for DNA detection
- Patent Title (中): 探针和DNA检测方法
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Application No.: US12932321Application Date: 2011-02-22
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Publication No.: US08476014B2Publication Date: 2013-07-02
- Inventor: Hsin-Chih Yeh , James Henry Werner , Jaswinder Kumar Sharma , Jennifer Suzanne Martinez
- Applicant: Hsin-Chih Yeh , James Henry Werner , Jaswinder Kumar Sharma , Jennifer Suzanne Martinez
- Applicant Address: US NM Los Alamos
- Assignee: Los Alamos National Security, LLC
- Current Assignee: Los Alamos National Security, LLC
- Current Assignee Address: US NM Los Alamos
- Agent Samuel L. Borkowsky
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12N15/11
Abstract:
A hybridization probe containing two linear strands of DNA lights up upon hybridization to a target DNA using silver nanoclusters that have been templated onto one of the DNA strands. Hybridization induces proximity between the nanoclusters on one strand and an overhang on the other strand, which results in enhanced fluorescence emission from the nanoclusters.
Public/Granted literature
- US20110212540A1 Probe and method for DNA detection Public/Granted day:2011-09-01
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