Invention Grant
- Patent Title: Methods relating to aromatase inhibitor pharmacogenetics
- Patent Title (中): 涉及芳香酶抑制剂药物遗传学的方法
-
Application No.: US12852957Application Date: 2010-08-09
-
Publication No.: US08476023B2Publication Date: 2013-07-02
- Inventor: Philip Lazarus , Dongxiao Sun
- Applicant: Philip Lazarus , Dongxiao Sun
- Applicant Address: US PA University Park
- Assignee: The Penn State Research Foundation
- Current Assignee: The Penn State Research Foundation
- Current Assignee Address: US PA University Park
- Agency: Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C.
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12N15/54 ; C12N15/52
Abstract:
Methods for aiding in determining therapeutic efficacy of an aromatase inhibitor in a subject are provided according to embodiments of the present invention which include detecting expression and/or function of at least one UDP-glucuronosyltransferase having activity to modify at least one aromatase inhibitor and/or metabolite of the aromatase inhibitor by glucuronidation, wherein detection of expression and/or function of the UDP-glucuronosyltransferase is correlated with therapeutic efficacy of the aromatase inhibitor in the subject. Detection of UDP-glucuronosyltransferase expression and/or function includes detection of a UDP-glucuronosyltransferase gene deletion polymorphism in the subject.
Public/Granted literature
- US20110033856A1 METHODS RELATING TO AROMATASE INHIBITOR PHARMACOGENETICS Public/Granted day:2011-02-10
Information query
