Invention Grant
US08476025B2 ATM-dependent phosphorylation of Sp1 is involved in the cellular response to DNA damage and enhances cellular survival after DNA damage
有权
Sp1的ATM依赖性磷酸化参与细胞对DNA损伤的反应,并增强DNA损伤后的细胞存活
- Patent Title: ATM-dependent phosphorylation of Sp1 is involved in the cellular response to DNA damage and enhances cellular survival after DNA damage
- Patent Title (中): Sp1的ATM依赖性磷酸化参与细胞对DNA损伤的反应,并增强DNA损伤后的细胞存活
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Application No.: US12187187Application Date: 2008-08-06
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Publication No.: US08476025B2Publication Date: 2013-07-02
- Inventor: Jane Clifford , Beatrix A. Olofsson , Crystal M. Kelly
- Applicant: Jane Clifford , Beatrix A. Olofsson , Crystal M. Kelly
- Applicant Address: US PA Philadelphia
- Assignee: Philadelphia Health and Education Corporation
- Current Assignee: Philadelphia Health and Education Corporation
- Current Assignee Address: US PA Philadelphia
- Agency: Riverside Law LLP
- Main IPC: G01N33/53
- IPC: G01N33/53

Abstract:
The present invention is related to the discovery that phosphorylation of SP1 (SEQ ID NO.: 2) at serine residue 101 (known herein as phosphoserine101 Sp1) is an important part of a cell's response to DNA damage. This phosphorylation event is important for subsequent Sp1 localization to a site of DNA damage and is correlated with increased cellular viability in response to DNA damage.
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