Invention Grant
- Patent Title: Bacillus strain for increased protein production
- Patent Title (中): 增加蛋白质生产的芽孢杆菌菌株
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Application No.: US13622968Application Date: 2012-09-19
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Publication No.: US08476042B2Publication Date: 2013-07-02
- Inventor: Cristina Bongiorni , Eugenio Ferrari
- Applicant: Danisco US Inc.
- Applicant Address: US CA Palo Alto
- Assignee: Danisco US Inc.
- Current Assignee: Danisco US Inc.
- Current Assignee Address: US CA Palo Alto
- Agency: Danisco US Inc.
- Main IPC: C12Q1/70
- IPC: C12Q1/70 ; C12N1/20 ; C12P21/06
Abstract:
The present invention provides host cells that have been genetically manipulated to have an enhanced capacity to produce proteins of interest. In particular, the invention relates to modified Bacillus sp. Host cells that have at least one inactivated phr gene. The enhanced production of proteins of interest by the modified Bacillus sp. Host cells is further increased in modified Bacillus sp. Host cells that overexpress YmaH. Methods for producing proteins of interest in the modified host cells are also provided.
Public/Granted literature
- US20130029402A1 BACILLUS STRAIN FOR INCREASED PROTEIN PRODUCTION Public/Granted day:2013-01-31
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