Invention Grant
- Patent Title: Insulinotropic complex using an immunoglobulin fragment
- Patent Title (中): 使用免疫球蛋白片段的胰岛素复合物
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Application No.: US12523050Application Date: 2008-01-04
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Publication No.: US08476230B2Publication Date: 2013-07-02
- Inventor: Dae Hae Song , Chang Ki Lim , Tae Hun Song , Young Hoon Kim , Se Chang Kwon , Gwan Sun Lee , Sung Youb Jung , In Young Choi
- Applicant: Dae Hae Song , Chang Ki Lim , Tae Hun Song , Young Hoon Kim , Se Chang Kwon , Gwan Sun Lee , Sung Youb Jung , In Young Choi
- Applicant Address: KR Hwaseong-si
- Assignee: Hanmi Science Co., Ltd
- Current Assignee: Hanmi Science Co., Ltd
- Current Assignee Address: KR Hwaseong-si
- Agency: Sughrue Mion, PLLC
- Priority: KR10-2007-0001662 20070105
- International Application: PCT/KR2008/000061 WO 20080104
- International Announcement: WO2008/082274 WO 20080710
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K39/395 ; A61P5/50
Abstract:
The present invention relates to an insulinotropic peptide conjugate having improved in-vivo duration of efficacy and stability, comprising an insulinotropic peptide, a non-peptide polymer and an immunoglobulin Fc region, which are covalently linked to each other, and a use of the same. The insulinotropic peptide conjugate of the present invention has the in-vivo activity which is maintained relatively high, and has remarkably increased blood half-life, and thus it can be desirably employed in the development of long acting formulations of various peptide drugs.
Public/Granted literature
- US20100105877A1 AN INSULINOTROPIC COMPLEX USING AN IMMUNOGLOBULIN FRAGMENT Public/Granted day:2010-04-29
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