Invention Grant
US08476275B2 N-[piperazinyl hetaryl]arylsufonamide compounds with affinity for the dopamine D3 receptor
失效
对多巴胺D3受体具有亲和力的N- [哌嗪基杂芳基]芳基磺酰胺化合物
- Patent Title: N-[piperazinyl hetaryl]arylsufonamide compounds with affinity for the dopamine D3 receptor
- Patent Title (中): 对多巴胺D3受体具有亲和力的N- [哌嗪基杂芳基]芳基磺酰胺化合物
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Application No.: US13117269Application Date: 2011-05-27
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Publication No.: US08476275B2Publication Date: 2013-07-02
- Inventor: Wilfried Braje , Andreas Haupt , Wilfried Lubisch , Roland Grandel , Karla Drescher , Herve Geneste , Liliane Unger , Daryl R. Sauer , Sean Colm Turner
- Applicant: Wilfried Braje , Andreas Haupt , Wilfried Lubisch , Roland Grandel , Karla Drescher , Herve Geneste , Liliane Unger , Daryl R. Sauer , Sean Colm Turner
- Applicant Address: DE Wiesbaden
- Assignee: Abbott GmbH & Co. KG
- Current Assignee: Abbott GmbH & Co. KG
- Current Assignee Address: DE Wiesbaden
- Agency: Michael Best & Friedrich LLP
- Agent Lisa V. Mueller
- Main IPC: A61K31/496
- IPC: A61K31/496 ; A61K31/506 ; C07D213/72 ; C07D213/74 ; C07D239/48
![N-[piperazinyl hetaryl]arylsufonamide compounds with affinity for the dopamine D3 receptor](/abs-image/US/2013/07/02/US08476275B2/abs.jpg.150x150.jpg)
Abstract:
The invention related to N-[(piperazinyl)hetaryl]arylsulfonamide compounds of the general formula (I) in which Q is a bivalent, 6-membered heteroaromatic radical which possesses 1 or 2 N atoms as ring members and which optionally carries one or two substituents Ra which is/are selected, independently of each other, from halogen, CN, NO2, CO2R4, COR5, C1-C4-alkyl and C1-C4-haloalkyl; Ar is phenyl or a 6-membered heteroaromatic radical which possesses 1 or 2 N atoms as ring members and which optionally carries one or two substituents Rb, which is/are selected from halogen, NO2, CN, CO2R4, COR5, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C4-alkyl and C1-C4-haloalkyl, with it also being possible for two radicals Rb which are bonded to adjacent C atoms of Ar to be together C3-C4-alkylene; R1 is hydrogen, C1-C4-alkyl, C1-C4-haloalkyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C4-alkyl, C1-C4-hydroxyalkyl, C1-C4-alkoxy-C1-C4-alkyl, C3-C4-alkenyl or C3-C4-alkynyl; with the radicals n, R1, R2, R3, R4 and R5 having the meanings given in the patent claims, to the N-oxides and to the physiologically tolerated acid addition salts of these compounds and to pharmaceutical compositions which comprise at least one N-[(piperazinyl)hetaryl]arylsulfonamide compound as claimed in one of claims 1 to 10 and/or at least one physiologically tolerated acid addition salt of I and/or an N-oxide of I, where appropriate together with physiologically acceptable carriers and/or auxiliary substances for treating diseases which respond to influencing by dopamine D3 receptor antagonists or agonists, in particular for treating diseases of the central nervous system and disturbances of kidney function.
Public/Granted literature
- US20110294817A1 N-[PIPERAZINYL HETARYL]ARYLSUFONAMIDE COMPOUNDS WITH AFFINITY FOR THE DOPAMINE D3 RECEPTOR Public/Granted day:2011-12-01
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