Invention Grant
US08476281B2 Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea
有权
回旋酶抑制剂（R）-1-乙基-3- [6-氟-5- [2-（1-羟基-1-甲基 - 乙基）嘧啶-5-基] -7-（四氢呋喃-2-基） 吡啶-2-基] -1H-苯并咪唑-2-基]脲
![Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea](/docs/US/2013-07-02/US08476281B2/abs.jpg.600x600.jpg)
- Patent Title: Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea
- Patent Title (中): 回旋酶抑制剂（R）-1-乙基-3- [6-氟-5- [2-（1-羟基-1-甲基 - 乙基）嘧啶-5-基] -7-（四氢呋喃-2-基） 吡啶-2-基] -1H-苯并咪唑-2-基]脲
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Application No.: US13349984Application Date: 2012-01-13
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Publication No.: US08476281B2Publication Date: 2013-07-02
- Inventor: Dean Shannon , Brian Luisi , Mariusz Krawiec , Anuj K. Kuldipkumar
- Applicant: Dean Shannon , Brian Luisi , Mariusz Krawiec , Anuj K. Kuldipkumar
- Applicant Address: US MA Cambridge
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Cambridge
- Agency: Brinks Hofer Gilson & Lione
- Agent William R. Boudreaux; Bashir M. Ali
- Main IPC: A01N43/54
- IPC: A01N43/54 ; C07D239/42 ; C07D471/04
![Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea](/abs-image/US/2013/07/02/US08476281B2/abs.jpg.150x150.jpg)
Abstract:
The present application is directed to solid forms of compounds of formula I: and pharmaceutically acceptable salts thereof, that inhibit bacterial gyrase and/or Topo IV and pharmaceutical compositions comprising said compounds and salts. These compounds and salts are useful in treating bacterial infections.
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