Invention Grant
US08476289B2 Aza-bicyclohexyl substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylace
有权
氮杂双环己基取代的吲哚基烷基氨基衍生物作为组蛋白脱乙酰基的新型抑制剂
- Patent Title: Aza-bicyclohexyl substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylace
- Patent Title (中): 氮杂双环己基取代的吲哚基烷基氨基衍生物作为组蛋白脱乙酰基的新型抑制剂
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Application No.: US12934894Application Date: 2009-03-26
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Publication No.: US08476289B2Publication Date: 2013-07-02
- Inventor: Eddy Jean Edgard Freyne , Isabelle Noëlle Constance Pilatte , Patrick René Angibaud
- Applicant: Eddy Jean Edgard Freyne , Isabelle Noëlle Constance Pilatte , Patrick René Angibaud
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE Beerse
- Priority: EP08153370 20080327
- International Application: PCT/EP2009/053566 WO 20090326
- International Announcement: WO2009/118370 WO 20091001
- Main IPC: C07D401/14
- IPC: C07D401/14 ; A61K31/506
Abstract:
This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4, A and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
Public/Granted literature
- US20110015218A1 AZA-BICYCLOHEXYL SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE Public/Granted day:2011-01-20
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