Invention Grant
US08476296B2 Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]OCT-3-yl)-3,5-difluorobenzamide
有权
（2S，3R）-N-2 - （（3-吡啶基）甲基）-1-氮杂双环[2.2.2] OCT-3-基）-3,5-二氟苯甲酰胺的制备和治疗应用
![Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]OCT-3-yl)-3,5-difluorobenzamide](/docs/US/2013-07-02/US08476296B2/abs.jpg.600x600.jpg)
- Patent Title: Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]OCT-3-yl)-3,5-difluorobenzamide
- Patent Title (中): （2S，3R）-N-2 - （（3-吡啶基）甲基）-1-氮杂双环[2.2.2] OCT-3-基）-3,5-二氟苯甲酰胺的制备和治疗应用
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Application No.: US12740970Application Date: 2010-01-25
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Publication No.: US08476296B2Publication Date: 2013-07-02
- Inventor: Merouane Bencherif , Nikolai Fedorov , Terry Hauser , Kristen Jordan , Sharon Rae Letchworth , Anatoly Mazurov , Julio A. Munoz , Jason Speake , Daniel Yohannes
- Applicant: Merouane Bencherif , Nikolai Fedorov , Terry Hauser , Kristen Jordan , Sharon Rae Letchworth , Anatoly Mazurov , Julio A. Munoz , Jason Speake , Daniel Yohannes
- Applicant Address: US NC Winston-Salem
- Assignee: Targacept, Inc.
- Current Assignee: Targacept, Inc.
- Current Assignee Address: US NC Winston-Salem
- Agent Amy H. Fix
- International Application: PCT/US2010/021926 WO 20100125
- International Announcement: WO2010/085724 WO 20100729
- Main IPC: A01N43/90
- IPC: A01N43/90 ; A61K31/44 ; C07D451/00 ; C07D453/02
![Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]OCT-3-yl)-3,5-difluorobenzamide](/abs-image/US/2013/07/02/US08476296B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).
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