Invention Grant
US08476432B2 Process for the preparation of HMG-COA reductase inhibitors and intermediates thereof
有权
制备HMG-COA还原酶抑制剂的方法及其中间体
- Patent Title: Process for the preparation of HMG-COA reductase inhibitors and intermediates thereof
- Patent Title (中): 制备HMG-COA还原酶抑制剂的方法及其中间体
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Application No.: US13806626Application Date: 2011-06-30
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Publication No.: US08476432B2Publication Date: 2013-07-02
- Inventor: Hyun Ju , Sang-Sun Joung , Hyun-Jik Yi , Ja-Heouk Khoo , Jong-Chul Lim , Jae-Gyu Kim
- Applicant: Hyun Ju , Sang-Sun Joung , Hyun-Jik Yi , Ja-Heouk Khoo , Jong-Chul Lim , Jae-Gyu Kim
- Applicant Address: KR Seoul
- Assignee: Yuhan Corporation
- Current Assignee: Yuhan Corporation
- Current Assignee Address: KR Seoul
- Agency: Vorys, Sater, Seymour and Pease LLP
- Agent Mih Suhn Koh
- Priority: KR10-2010-0063604 20100701
- International Application: PCT/KR2011/004783 WO 20110630
- International Announcement: WO2012/002741 WO 20120105
- Main IPC: C07D239/42
- IPC: C07D239/42 ; C07D215/12 ; C07D405/06 ; C07D209/10 ; C07D257/04
Abstract:
The present invention provides an improved process for preparing HMG-CoA reductase inhibitors such as rosuvastatin calcium, fluvastatin sodium, and pitavastatin calcium under a mild condition, using a novel amide-bond-containing compound having R2—N—O—R1 moiety as a key intermediate. And also, the present invention provides the novel compound, an intermediate useful for the preparation thereof, and a process for the preparation thereof.
Public/Granted literature
- US20130096303A1 PROCESS FOR THE PREPARATION OF HMG-COA REDUCTASE INHIBITORS AND INTERMEDIATES THEREOF Public/Granted day:2013-04-18
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