Invention Grant
- Patent Title: Process for preparing an intermediate to mu opioid receptor antagonists
- Patent Title (中): 制备中间体至阿片受体拮抗剂的方法
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Application No.: US13551774Application Date: 2012-07-18
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Publication No.: US08476440B2Publication Date: 2013-07-02
- Inventor: Pierre-Jean Colson , Ying Yu , Daniel D. Long , Ioanna Stergiades
- Applicant: Pierre-Jean Colson , Ying Yu , Daniel D. Long , Ioanna Stergiades
- Applicant Address: US CA South San Francisco
- Assignee: Theravance, Inc.
- Current Assignee: Theravance, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Roberta P. Saxon
- Main IPC: C07D451/02
- IPC: C07D451/02
Abstract:
The invention provides an efficient method for preparing 3-endo-(8-azabicyclo[3.2.1]oct-3-yl)benzamide by hydrogenation, under controlled conditions, of an amino-protected 3-(8-azabicyclo[3.2.1]oct-2-en-3-yl)benzamide intermediate in which the amino-protecting group is removable by catalytic hydrogenation.
Public/Granted literature
- US20130079523A1 PROCESS FOR PREPARING AN INTERMEDIATE TO MU OPIOID RECEPTOR ANTAGONISTS Public/Granted day:2013-03-28
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