Invention Grant
US08476441B2 Intermediates in the enantioselective synthesis of 3-(aminomethyl)-5-methyl-hexanoic acid
有权
3-（氨基甲基）-5-甲基 - 己酸的对映选择性合成中的中间体
- Patent Title: Intermediates in the enantioselective synthesis of 3-(aminomethyl)-5-methyl-hexanoic acid
- Patent Title (中): 3-（氨基甲基）-5-甲基 - 己酸的对映选择性合成中的中间体
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Application No.: US13146491Application Date: 2010-01-29
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Publication No.: US08476441B2Publication Date: 2013-07-02
- Inventor: Stephen Joseph Connon , Aldo Peschiulli , Lyn Markey
- Applicant: Stephen Joseph Connon , Aldo Peschiulli , Lyn Markey
- Applicant Address: IE Dublin
- Assignee: The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin
- Current Assignee: The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin
- Current Assignee Address: IE Dublin
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Priority: EP09151679 20090129
- International Application: PCT/EP2010/051133 WO 20100129
- International Announcement: WO2010/086429 WO 20100805
- Main IPC: C07C327/32
- IPC: C07C327/32 ; C07C67/12 ; C07C227/06 ; C07D453/02
Abstract:
(S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid or (S)-pregabalin is an anticonvulsive drug. In addition to its use as an anticonvulsive agent, pregabalin has also been indicated as a medicament in the treatment of anxiety, neuropathic pain and pain in patients with fibromyalgia. Provided herein are thioester intermediates in the synthesis of and processes for the synthesis of 3-(aminomethyl)-5-methyl-hexanoic acid in the (R) or (S) configuration.
Public/Granted literature
- US20120046468A1 INTERMEDIATES IN THE ENANTIOSELECTIVE SYNTHESIS OF 3-(AMINOMETHYL)-5-METHYL-HEXANOIC ACID Public/Granted day:2012-02-23
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