Invention Grant
- Patent Title: Tubulysin D analogues
- Patent Title (中): Tubulysin D类似物
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Application No.: US12669364Application Date: 2008-07-21
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Publication No.: US08476451B2Publication Date: 2013-07-02
- Inventor: Jonathan A. Ellman , Andrew W. Patterson , Hillary Peltier
- Applicant: Jonathan A. Ellman , Andrew W. Patterson , Hillary Peltier
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Morgan, Lewis & Bockius LLP
- Agent Jeffrey S. Mann
- International Application: PCT/US2008/070677 WO 20080721
- International Announcement: WO2009/134279 WO 20091105
- Main IPC: A61K31/426
- IPC: A61K31/426 ; A61K31/427 ; C07D277/30 ; A01N43/78
Abstract:
The present invention provides novel tubulysin analogues, methods of making and methods of using such analogues and conjugates thereof. The compounds of the invention are highly potent cell-growth inhibitors have been developed that are smaller and considerably more stable than tubulysin D.
Public/Granted literature
- US20110021568A1 TUBULYSIN D ANALOGUES Public/Granted day:2011-01-27
Information query
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